Optimal Being

New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting. The results demonstrate evidence of health benefits beyond weight loss, but also show that any potentially health-altering changes appear to occur only after three days without food. New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting. The results demonstrate evidence of health benefits beyond weight loss, but also show that any potentially health-altering changes appear to occur only after three days without food. The study, published today in  Nature Metabolism,  advances our understanding of what's happening across the body after prolonged periods without food. By identifying the potential health benefits from fasting and their underlying molecular basis, researchers from Queen Mary University of London's Precision Healthcare University Research Institute (PH...

Scientists are intrigued by a drug that appears to imbue mice with the benefits of exercise without actually getting physical activity — but as you'd imagine, there are caveats, so don't throw out your workout clothes just yet. As a  University of Florida press release  about the new research declares, the newly developed compound SLU-PP-332 led obese mice to lose weight by apparently convincing their bodies to go into marathon training mode, leading to a faster metabolism and more energy and endurance, and all without actually exercising. "This compound is basically telling skeletal muscle to make the same changes you see during endurance training," Thomas Burris, a UF pharmacy professor who led the research, said in the school's press release. SLU-PP-332 purports to achieve this by targeting what are known as EFF proteins that activate the body's most "energy-gobbling" tissues, such as the brain, the heart, and other muscles. ERRs are naturally rel...